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dc.contributor.authorBravo García, Lidia 
dc.contributor.authorAlba-Delgado, Cristina
dc.contributor.authorTorres-Sanchez, Sonia
dc.contributor.authorMicó Segura, Juan Antonio 
dc.contributor.authorNeto, Fani L.
dc.contributor.authorBerrocoso Domínguez, Esther María 
dc.contributor.otherNeurocienciasen_US
dc.date.accessioned2014-03-19T10:56:34Z
dc.date.available2014-03-19T10:56:34Z
dc.date.issued2014-03-19T00:00:00Z
dc.identifier.issn0304-3959
dc.identifier.urihttp://hdl.handle.net/10498/15967
dc.description.abstractStressful experiences seem to negatively influence pain perception through as yet unknown mechanisms. As the noradrenergic locus coeruleus (LC) nucleus coordinates many components of the stress response, as well as nociceptive transmission, we evaluated whether the sensory and affective dimension of chronic neuropathic pain worsens in situations of stress due to adaptive changes of LC neurons. Accordingly, male rats were socially isolated for 5 weeks, and in the last 2 weeks, neuropathic pain was induced by chronic constriction injury. In this situation of stress, chronic pain selectively heightened the animal's aversion to painful experiences (affective pain), as measured in the place escape/avoidance test, although no changes were observed in the sensory dimension of pain. In addition, electrophysiological recordings of LC neurons showed a low tonic but exacerbated nociceptive-evoked activity when the injured paw was stimulated. These changes were accompanied by an increase in tyrosine hydroxylase and gephyrin expression in the LC. Furthermore, intra-LC administration of bicuculline, a γ-aminobutyric acid-A receptor antagonist, attenuated the negative affective effects of pain. These data show that changes in the LC are greater than those expected from the simple summation of each independent factor (pain and stress), revealing mechanisms through which stressors may exacerbate pain perception without affecting the sensorial dimensionen_US
dc.formatapplication/pdf
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcePain - 2013, Vol. 154 n.10 pp. 2014-2023en_US
dc.subjectpainen_US
dc.subjectchronic stressen_US
dc.subjectisolationen_US
dc.subjectGABAen_US
dc.subjectlocus coeruleusen_US
dc.titleSocial stress exacerbates the aversion to painful experiences in rats exposed to chronic pain: the role of the locus coeruleusen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doi10.1016/j.pain.2013.06.021


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