Asymmetric preparation of antifungal 1-(4 -chlorophenyl)-1-cyclopropyl methanol and 1-(4 -chlorophenyl)-2-phenylethanol. Study of the detoxification mechanism by Botrytis cinerea
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Author/sPinedo Rivilla, Cristina; Aleu Casatejada, Josefina; Hernández Galán, Rosario; González Collado, Isidro; Bustillo Pérez, Antonio
SourceJournal of Molecular Catalysis B: Enzymatic, 2011, vol. 70, pp. 61–66
Chiral alcohols are important as bioactive compounds or as precursors to such molecules. On the basis of the different antifungal properties of the enantiopure alcohol derivatives of 4-chlorophenyl cyclopropyl ketone and benzyl 4-chlorophenyl ketone, their enantioselective synthesis by chemical and biocatalytic methods was studied. The detoxification pathways by the phytopathogen fungus Botrytis cinerea are reported.