Show simple item record

dc.contributor.authorBaena-Nogueras, Rosa María
dc.contributor.authorPintado-Herrera, Marina G.
dc.contributor.authorGonzález-Mazo, Eduardo
dc.contributor.authorLara-Martín, Pablo A.
dc.contributor.otherQuímica Físicaen_US
dc.date.accessioned2015-12-03T07:38:28Z
dc.date.available2015-12-03T07:38:28Z
dc.date.issued2015-10-01T00:00:00Z
dc.identifier.issn1875-6727
dc.identifier.issn1573-4110
dc.identifier.urihttp://hdl.handle.net/10498/17946
dc.description.abstractThis paper describes the optimization and validation of an analytical method for the determination of 83 pharmaceutically active compounds (PhACs) in aqueous samples using solid-phase extraction (SPE) followed by ultra performance liquid chromatography-triple quadrupole mass spectrometry (UPLC-QqQ-MS/MS). First, several experiments were conducted to optimize different SPE extraction parameters such as pH, elution solvents, and Na2EDTA addition. Extraction recovery percentages were between 17 and 146%, being higher than 70% for 47 target analytes. The effect of salinity in the extraction efficiency proved to be negligible (< 20% within a range from 0 to 38 g L-1). The method limits of detection (LOD) and quantification (LOQ) were below 1 ng L-1 for most compounds (> 90%), and the precision of the method, calculated as the relative standard deviation (RSD) of replicate extractions and analyses, was less than 20%. The optimized method was successfully applied to the analysis of real water samples in estuarine and coastal systems from SW Spain (Cadiz Bay and Huelva Estuary). 49 out of 83 target compounds were found in 75% of samples. Ibuprofen, atenolol, gemfibrozil and caffeine were the most commonly detected substances, reaching concentrations up to 195 ng L-1.en_US
dc.formatapplication/pdfen_US
dc.language.isoengen_US
dc.publisherSamuel Achilefuen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.sourceCurrent Analytical Chemistry 2015, Vol. 11, 4 Issues, 1-19en_US
dc.subjectAntibioticsen_US
dc.subjectestuaryen_US
dc.subjectmass spectrometryen_US
dc.subjectpharmaceuticalsen_US
dc.subjectseawateren_US
dc.subjectsolid phase extractionen_US
dc.titleDetermination of Pharmaceuticals in Coastal Systems Using Solid Phase Extraction (SPE) Followed by Ultra Performance Liquid Chromatography – tandem Mass Spectrometry (UPLC-MS/MS)en_US
dc.typeinfo:eu-repo/semantics/preprinten_US
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen_US
dc.identifier.doi10.2174/1573411012666151009193254


Files in this item

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This work is under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 Internacional