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dc.contributor.authorMacías Domínguez, Francisco Antonio
dc.contributor.authorCarrera Fernández, Ceferino
dc.contributor.authorG. Galindo, Juan C.
dc.contributor.otherQuímica Orgánicaen_US
dc.date.accessioned2018-04-06T09:57:06Z
dc.date.available2018-04-06T09:57:06Z
dc.date.issued2014-03
dc.identifier.urihttp://hdl.handle.net/10498/20303
dc.description.abstractBreviones are a new family of secondary metabolites that were originally isolated from the New Zealand endemic fungus Penicillium brevicompactum var. Dierckx. These compounds are generally characterized by a new carbon skeleton, known as breviane, which that has three possible structural variations, such as breviane, abeo-breviane, and abeo-norbreviane. Brevianes present a basic diterpenic tricyclic core that is mevalonic in origin and is similar to that of perhydrophenanthrene. The core bears four methyl groups at positions C4, C8, C10, and C13 and has defined stereochemistry at positions C5, C8, C9, C10, and C14. The C1'-C7' side chain has been proposed to have a polyketide biosynthetic origin and is joined to the diterpenic moiety through carbons C2'-C15'. The cyclization and lactonization of this part of the molecule leads to the characteristic breviane spiranic ring fused to the α-pyrone.en_US
dc.formatapplication/pdfen_US
dc.language.isoengen_US
dc.publisherChemical Reviewsen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceChem. Rev. 2014, 114, 2717−2732en_US
dc.subjectsynthesisen_US
dc.subjectbioactivityen_US
dc.subjectbiogenetic pathwayen_US
dc.subjectcarbon skeletonen_US
dc.subjectlactonizationen_US
dc.subjectpolyketidesen_US
dc.subjectsecondary metabolitesen_US
dc.titleBrevianes Revisiteden_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen_US
dc.identifier.doi10.1021/cr300048m


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This work is under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 Internacional