Acyloxylation of Cyclic Enones: Synthesis of Densely Oxygenated Guaianolides

dc.contributor.author	Marín Barrios, Rubén
dc.contributor.author	García-Cabeza, Ana Leticia
dc.contributor.author	Moreno Dorado, Francisco Javier
dc.contributor.author	Guerra, Francisco M.
dc.contributor.author	Martínez Massanet, Guillermo
dc.contributor.other	Química Orgánica	en_US
dc.date.accessioned	2018-04-19T12:15:55Z
dc.date.available	2018-04-19T12:15:55Z
dc.date.issued	2014-06
dc.identifier.uri	http://hdl.handle.net/10498/20367
dc.description.abstract	The α′-acyloxylation of cyclic enones with linear carboxylic acids is described. The reaction is promoted by KMnO4 in the presence of a carboxylic acid and its corresponding carboxylic anhydride. The optimization of the reaction has been carried out using the statistical methodology known as design of experiments. The optimized reaction conditions have been evaluated in terms of substrate scope and compatibility with different functional groups. The methodology has been applied to the synthesis of densely oxygenated guaianes and guaianolides.	en_US
dc.format	application/pdf	en_US
dc.language.iso	eng	en_US
dc.publisher	ACS Publications	en_US
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.source	Journal of Organic Chemistry 2014, 79, 6501−6509	en_US
dc.title	Acyloxylation of Cyclic Enones: Synthesis of Densely Oxygenated Guaianolides	en_US
dc.type	journal article	en_US
dc.rights.accessRights	closed access
dc.identifier.doi	10.1021/jo500915r

This work is under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 Internacional