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dc.contributor.authorGarcía-Cabeza, Ana Leticia
dc.contributor.authorP. Ray, Lindsey
dc.contributor.authorMarín-Barrios, Rubén
dc.contributor.authorMoreno-Dorado, F. Javier
dc.contributor.authorGuerra, Francisco M.
dc.contributor.authorOrtega Aguera, María Jesús
dc.contributor.authorMartínez Massanet, Guillermo
dc.contributor.otherQuímica Orgánicaen_US
dc.date.accessioned2018-04-19T12:29:59Z
dc.date.available2018-04-19T12:29:59Z
dc.date.issued2015-09
dc.identifier.urihttp://hdl.handle.net/10498/20370
dc.description.abstractResponse surface methodology (RSM) has been employed to model and optimize the Kharasch−Sosnovsky allylic oxidation of valencene. The detailed effects of the amounts of oxidant, substrate, copper catalyst, 1,8- diazabicyclo[5.4.0]undec-7-ene (DBU), and temperature have been studied. The concentration of substrate and quantity of oxidant have been determined as the most significant variables. The interaction effects on the yield have been investigated using a three-level full-factorial design. The yield of benzoyloxyvalencene has been improved to 99%. Analysis of variance (ANOVA) has been used to evaluate the goodness of fit of the model.en_US
dc.formatapplication/pdfen_US
dc.language.isoengen_US
dc.publisherACS Publicationsen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceOrganic Process Research & Development 2015, 19, 1662−1666en_US
dc.titleOptimization by Response Surface Methodology (RSM) of the Kharasch−Sosnovsky Oxidation of Valenceneen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.identifier.doi10.1021/op5002462


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This work is under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 Internacional