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dc.contributor.authorMarín-Barrios, Rubén
dc.contributor.authorGuerra, Francisco M.
dc.contributor.authorGarcía-Cabeza, Ana Leticia
dc.contributor.authorMoreno-Dorado, F. Javier
dc.contributor.authorMartínez Massanet, Guillermo
dc.contributor.otherQuímica Orgánicaen_US
dc.date.accessioned2018-05-14T11:49:09Z
dc.date.available2018-05-14T11:49:09Z
dc.date.issued2012-01
dc.identifier.urihttp://hdl.handle.net/10498/20503
dc.description.abstractThe multivariate optimization method known as simplex is applied to the KharascheSosnovsky allylic oxidation of double bonds. By applying this method, the amounts of three variables (copper source, oxidant, and additive) are optimized at the same time. Under the conditions thus obtained the reaction takes place in a considerable shorter time, being the alkene the limiting reagent. These conditions are applied to some monoterpenes and sesquiterpenes leading regioselectively to the corresponding benzoate esters, opening a route to the employment of this reaction in the synthesis of more complex molecules.en_US
dc.formatapplication/pdfen_US
dc.language.isoengen_US
dc.publisherTetrahedronen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceTetrahedron 68 (2012) 1105e1108en_US
dc.subjectallylic oxidationen_US
dc.subjectolefinsen_US
dc.subjectkharasch-sosnovsky reactionen_US
dc.subjectsimplexen_US
dc.subjectmultivariate optimizationen_US
dc.titleMultivariate optimization of the KharascheSosnovsky allylic oxidation of olefinsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.identifier.doi10.1016/j.tet.2011.11.083


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This work is under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 Internacional