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dc.contributor.authorBotubol Ares, José Manuel
dc.contributor.authorDurán-Peña, María Jesús
dc.contributor.authorMacías Sánchez, Antonio José
dc.contributor.authorR. Hanson, James
dc.contributor.authorGonzález Collado, Isidro
dc.contributor.authorHernández Galán, Rosario
dc.contributor.otherQuímica Orgánicaen_US
dc.date.accessioned2018-06-01T10:09:56Z
dc.date.available2018-06-01T10:09:56Z
dc.date.issued2014-11
dc.identifier.urihttp://hdl.handle.net/10498/20578
dc.description.abstractThe structure 3,4-dihydroxy-2,4,6,8-tetramethyldec-8-enolide (1) was assigned to a metabolite of Botrytis cinerea, but the spectra of several synthetic analogues had significant differences from that of 1. Examination of the constituents of a B. cinerea mutant that overproduces polyketides gave sufficient quantities of 1, now named cinbotolide, for chemical transformations. These led to a revised γ-butyrolactone structure for the metabolite. This structure has been confirmed by an asymmetric total synthesis, which also established its absolute configuration.en_US
dc.formatapplication/pdfen_US
dc.language.isoengen_US
dc.publisherACS Publicationsen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceThe Journal of Organic Chemistry 2014, 79, 11349−11358en_US
dc.titleThe Asymmetric Total Synthesis of Cinbotolide: A Revision of the Original Structureen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.identifier.doi10.1021/jo501471m


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This work is under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 Internacional