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dc.contributor.authorHierro Bujalance, Carmen
dc.contributor.authorInfante Garcia, Carmen
dc.contributor.authorSanchez Sotano, Daniel
dc.contributor.authorMarco González, Ángel José del
dc.contributor.authorCasado Revuelta, Ana
dc.contributor.authorMengual Gonzalez, Carmen Maria
dc.contributor.authorLucena Porras, Carmen
dc.contributor.authorBernal Martin, Marcos
dc.contributor.authorBenavente Fernández, Isabel 
dc.contributor.authorLubián López, Simón Pedro 
dc.contributor.authorGarcía Alloza, Mónica 
dc.contributor.otherBiomedicina, Biotecnología y Salud Públicaes_ES
dc.date.accessioned2020-11-18T08:00:12Z
dc.date.available2020-11-18T08:00:12Z
dc.date.issued2020-09
dc.identifier.issn2296-634X
dc.identifier.urihttp://hdl.handle.net/10498/23940
dc.description.abstractThe germinal matrix-intraventricular hemorrhage (GM-IVH) is one of the most devastating complications of prematurity. The short- and long-term neurodevelopmental consequences after severe GM-IVH are a major concern for neonatologists. These kids are at high risk of psychomotor alterations and cerebral palsy; however, therapeutic approaches are limited. Erythropoietin (EPO) has been previously used to treat several central nervous system complications due to its role in angiogenesis, neurogenesis and as growth factor. In addition, EPO is regularly used to reduce the number of transfusions in the preterm infant. Moreover, EPO crosses the blood-brain barrier and EPO receptors are expressed in the human brain throughout development. To analyze the role of EPO in the GM-IVH, we have administered intraventricular collagenase (Col) to P7 mice, as a model of GM-IVH of the preterm infant. After EPO treatment, we have characterized our animals in the short (14 days) and the long (70 days) term. In our hands, EPO treatment significantly limited brain atrophy and ventricle enlargement. EPO also restored neuronal density and ameliorated dendritic spine loss. Likewise, inflammation and small vessel bleeding were also reduced, resulting in the preservation of learning and memory abilities. Moreover, plasma gelsolin levels, as a feasible peripheral marker of GM-IVH-induced damage, recovered after EPO treatment. Altogether, our data support the positive effect of EPO treatment in our preclinical model of GM-IVH, both in the short and the long term.es_ES
dc.formatapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherFRONTIERS MEDIA SAes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceFront. Cell Dev. Biol. 8:571258es_ES
dc.subjectbrain atrophyes_ES
dc.subjectneuronal losses_ES
dc.subjecterythropoietines_ES
dc.subjectgelsolines_ES
dc.subjectgerminal matrix-intraventricular hemorrhagees_ES
dc.subjectpreterm infantes_ES
dc.titleErythropoietin Improves Atrophy, Bleeding and Cognition in the Newborn Intraventricular Hemorrhagees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3389/fcell.2020.571258


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