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dc.contributor.authorBlancas, I.
dc.contributor.authorOlier, C.
dc.contributor.authorConde, V.
dc.contributor.authorBayo, J.L.
dc.contributor.authorHerrero, C.
dc.contributor.authorZarcos‑Pedrinaci, I.
dc.contributor.authorCarabantes, F.
dc.contributor.authorBaena Cañada, José Manuel
dc.contributor.authorCruz, J.
dc.contributor.authorRuiz‑Borrego, M.
dc.contributor.otherMedicinaes_ES
dc.date.accessioned2021-04-09T09:03:40Z
dc.date.available2021-04-09T09:03:40Z
dc.date.issued2021-02
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10498/24691
dc.description.abstractGoals of endocrine therapy for advanced breast cancer (ABC) include prolonging survival rates, maintaining the quality of life, and delaying the initiation of chemotherapy. We evaluated the effectiveness of fulvestrant as first-line in patients with estrogen receptor (ER)-positive ABC with relapse during or after adjuvant anti-estrogenic therapy in real-world settings. Retrospective, observational study involving 171 postmenopausal women with ER-positive ABC who received fulvestrant as first-line between January 2011 and May 2018 in Spanish hospitals. With a median follow-up of 31.4 months, the progression-free survival (PFS) with fulvestrant was 14.6 months. No differences were seen in the visceral metastatic (14.3 months) versus non-visceral (14.6 months) metastatic subgroup for PFS. Overall response rate and clinical benefit rate were 35.2% and 82.8%. Overall survival was 43.1 months. The duration of the clinical benefit was 19.2 months. Patients with ECOG performance status 0 at the start of treatment showed a significant greater clinical benefit rate and overall survival than with ECOG 1-2. Results in real-world settings are in concordance with randomized clinical trials. Fulvestrant continues to demonstrate clinical benefits in real-world settings and appears be well tolerated as first-line for the treatment of postmenopausal women with ER-positive ABC.es_ES
dc.formatapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherNATURE RESEARCHes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceSci Rep 11, 4274 (2021)es_ES
dc.titleReal-world data of fulvestrant as first-line treatment of postmenopausal women with estrogen receptor-positive metastatic breast canceres_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1038/s41598-021-83622-1


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Atribución 4.0 Internacional
This work is under a Creative Commons License Atribución 4.0 Internacional