Microwave-Enhanced Coupling of Carboxylic Acids with Liquid Ketones and Cyclic Ethers Using Tetrabutylammonium Iodide/t-Butyl Hydroperoxide

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URI: http://hdl.handle.net/10498/33912

DOI: 10.1021/acs.joc.0c00519

ISSN: 1520-6904

ISSN: 0022-3263

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Author/s
Macías Benítez, PabloAuthority UCA; Moreno Dorado, Francisco JavierAuthority UCA; Guerra Martínez, Francisco MiguelAuthority UCA
Date
2020
Department
Química Orgánica
Source
J. Org. Chem. 2020, 85, 6027−6043
Abstract
The oxidative coupling of carboxylic acids with liquid ketones and cyclic ethers has been accomplished in minutes using t-butyl hydroperoxide in the presence of tetrabutylammonium iodide under microwave irradiation in the absence of a solvent. In addition to drastically shortening the reaction times, the use of microwaves resulted, in general, in yields equal to or higher than those obtained by conventional heating.
Subjects
carboxylic acid; ketone; cyclic ether; oxidative coupling; microwave irradiation; ester preparation
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This work is under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 Internacional