RT journal article
T1 Environmentally friendly analysis of emerging contaminants by pressurized hot water extraction-stir bar sorptive extraction-derivatization and gas chromatography-mass spectrometry
A1 Pintado Herrera, Marina Guadalupe
A1 González Mazo, Eduardo
A1 Lara Martín, Pablo Antonio
A2 Química Física
K1 extraction
K1 emerging compounds
K1 GC-MS
AB This work describes the development, optimiza-tion, and validation of a new method for the simultaneousdetermination of a wide range of pharmaceuticals (beta-blockers, lipid regulators...) and personal care products(fragrances, UV filters, phthalates...) in both aqueous andsolid environmental matrices. Target compounds wereextracted from sediments using pressurized hot water ex-traction followed by stir bar sorptive extraction. The firststage was performed at 1,500 psi during three static extrac-tion cycles of 5 min each after optimizing the extractiontemperature (50–150 °C) and addition of organic modifiers(% methanol) to water, the extraction solvent. Next, aqueousextracts and water samples were processed using polydime-thylsiloxane bars. Several parameters were optimized forthis technique, including extraction and desorption time,ionic strength, presence of organic modifiers, and pH. Fi-nally, analytes were extracted from the bars by ultrasonicirradiation using a reduced amount of solvent (0.2 mL) priorto derivatization and gas chromatography–mass spectrome-try analysis. The optimized protocol uses minimal amountsof organic solvents (<10 mL/sample) and time (≈8 h/sam-ple) compared to previous existing methodologies. Lowstandard deviation (usually below 10 %) and limits of de-tection (sub-ppb) vouch for the applicability of the method-ology for the analysis of target compounds at trace levels.Once developed, the method was applied to determine
PB Springer
YR 2013
FD 2013-01-01T00:00:00Z
LK http://hdl.handle.net/10498/17233
UL http://hdl.handle.net/10498/17233
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026