RT doctoral thesis
T1 Incorporación de vitamina C en dietas larvarias y su implicación en el desarrollo de Solea senegalensis
T2 Controlled delivery of vitamin C through larval diets and its effects on Solea senegalensis larval development
A1 Jiménez Fernández, Eduardo
A2 Biología
K1 Solea senegalensis
K1 Vitamin C
K1 Nanoparticles
K1 Iron
K1 Larvae
K1 Microparticles
K1 Antioxidants
K1 Microdiet
K1 Larval performance
K1 First feeding
K1 slc23a1
K1 slc23a2
K1 Metamorphosis
K1 Chitosan
K1 ZFL cells
K1 Cytotoxicity
AB This thesis is a contribution to advancing the knowledge on the role of an essential micronutrient for marine fish, vitamin C, during the larval stage. The study was carried out using an important aquaculture species, the Senegalese sole. Technologies were developed that allowed controlled dosage and form of presentation of vitamin C. An important part of the thesis was devoted to study the potential of nanotechnology in aquaculture. Three different types of nanoparticles were designed, developed and evaluate. Nanoparticles were obtained after using different techniques including the use of various materials and water-soluble compounds. In addition, the safety and efficacy of these techniques for water-soluble compound delivering in aquaculture were tested. The formulation, the microencapsulation protocol and the culture system used, allowed the replacement of rotifers during the first feeding stage of sole and enabled a nutritional study to be conducted. Ascorbyl palmitate is a source of vitamin C available for the first larval stages of sole. The nutritional study performed as part of this thesis revealed the important role of vitamin C in the larval stage of soles and the impact of vitamin deficiency during first feeding on the development and antioxidant defence system and its involvement in various metabolic pathways. The pattern of ascorbic acid content during the larval stage of sole was also determined and, for the first time, a mechanism of vitamin C transport at the molecular level was identified in this species. Vitamin C in sole has an important role in the regulation of iron metabolism. A higher dietary intake of iron and vitamin C to sole larvae resulted in improved growth, antioxidant balance and improved histological and skeletal development.
YR 2015
FD 2015-04-23T00:00:00Z
LK http://hdl.handle.net/10498/17342
UL http://hdl.handle.net/10498/17342
LA eng
NO Eduardo Jiménez Fernández has been supported by a PhD fellowship of CICE (Consejería de Innovación, Ciencia y Empresa, Junta de Andalucía) and funded by the Operational of European Social Fund of Andalucía, within the priority axis 3 (Expand and improve investment in human capital) in 80% within the period 2009-2013.This study has been funded by proyect AGR3695 (CICE, Junta de Andalucía) and partially by proyects Interreg Cooperación Transfronteriza ECOAQUA (Supported by FEDER fund) and AQUAGENET (SOE2/P1/E287) program INTERREG IVB SUDUE (ERDF/FEDER).
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026