RT journal article
T1 Global Antifungal Profile Optimization of Chlorophenyl Derivatives against Botrytis cinerea and Colletotrichum gloeosporioides
A1 Bustillo Pérez, Antonio
A1 Pinedo Rivilla, Cristina
A1 Aleu Casatejada, Josefina
A1 González Collado, Isidro
A1 Hernández Galán, Rosario
A1 Saiz-Urra, Liane
A1 Cruz-Monteagudo, Maykel
A2 Química Orgánica
K1 Antifungal
K1 Botrytis cinerea
K1 Colletotrichum gloeosporioides
K1 Chlorophenyl derivatives
K1 crop-protection agents
K1 MOOP-DESIRE methodology
K1 3D molecular descriptors
AB Twenty-two aromatic derivatives bearing a chlorine atom and a different chain in the para or metaposition were prepared and evaluated for their in vitro antifungal activity against the phytopathogenicfungi Botrytis cinerea and Colletotrichum gloeosporioides. The results showed that maximum inhibitionof the growth of these fungi was exhibited for enantiomers S and R of 1-(40-chlorophenyl)-2-phenylethanol (3 and 4). Furthermore, their antifungal activity showed a clear structure-activityrelationship (SAR) trend confirming the importance of the benzyl hydroxyl group in the inhibitorymechanism of the compounds studied. Additionally, a multiobjective optimization study of theglobal antifungal profile of chlorophenyl derivatives was conducted in order to establish a rationalstrategy for the filtering of new fungicide candidates from combinatorial libraries. The MOOPDESIREmethodology was used for this purpose providing reliable ranking models that can beused later.
SN 0021-8561
YR 2009
FD 2009-05-18T00:00:00Z
LK http://hdl.handle.net/10498/17358
UL http://hdl.handle.net/10498/17358
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026