RT journal article
T1 Biocatalytic preparation and absolute configuration of enantiomerically pure fungistatic anti-2-benzylindane derivatives. Study of the detoxification mechanism by Botrytis cinerea
A1 Pinedo Rivilla, Cristina
A1 Aleu Casatejada, Josefina
A1 Grande Benito, Manuel
A1 González Collado, Isidro
A2 Química Orgánica
K1 anti-2-benzylindane
K1 Biocatalytic
K1 Botrytis cinerea
AB Enantiomerically pure 2-benzylindane derivatives were prepared using biocatalytic methods and theirabsolute configuration determined. (1R,2S)-2-Benzylindan-1-ol ((1R,2S)-2) and(S)-2-benzylindan-1-one ((S)-3) were produced by fermenting baker’s yeast. Lipase-mediatedesterifications and hydrolysis of the corresponding racemic substrates gave rise to the enantiopurecompounds (1S,2R)-2-benzylindan-1-ol ((1S,2R)-2) and (1R,2S)-2-benzylindan-1-ol ((1R,2S)-2),respectively. The antifungal activity of these products against two strains of the plant pathogen Botrytiscinerea was tested. The metabolism of anti-(±)-2-benzylindan-1-ol (anti-(±)-2) by B. cinerea as part ofthe fungal detoxification mechanism is also described and revealed interesting differences in the genomeof both strains.
PB Royal Society of Chemistry
YR 2010
FD 2010-06-23T00:00:00Z
LK http://hdl.handle.net/10498/17360
UL http://hdl.handle.net/10498/17360
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026