RT journal article
T1 Facile Preparation of Bioactive seco-Guaianolides and Guaianolides from Artemisia gorgonum and Evaluation of Their Phytotoxicity
A1 Macías Domínguez, Francisco Antonio
A1 Santana, Alejandro
A1 Yamahata, Azusa
A1 Varela Montoya, Rosa María
A1 R. Fronczek, Frank
A1 González Molinillo, José María
A2 Química Orgánica
K1 phytotoxicity
K1 artemisia gorgonum
K1 bioactive
K1 seco-guaianolides
K1 guaianolides
K1 preparation
K1 evaluation
K1 organic chemistry
K1 chemistry
K1 gorgonum
K1 artemisia
AB Commercially available santonin was used to synthesize seven sesquiterpene lactones using a facile strategy that involved a high-yielding photochemical reaction. Three natural products from Artemisia gorgonum were synthesized in good yields, and in the case of two compounds, absolute configurations were determined from X-ray quality crystals. The structures previously reported for these compounds were revised. Sesquiterpene lactones were tested using the etiolated wheat coleoptile bioassay, and the most active compounds were assayed in standard target species. seco-Guaianolide (4) showed higher phytotoxic activities than the known herbicide Logran. This high activity could be due to the presence of a cyclopentenedione ring. These results suggest that compound 4 should be involved in defense of A. gorgorum, displaying a wide range of activities that allow proposing them as new leads for development of a natural herbicide model with a seco-guaianolide skeleton.
PB Journal of Natural Products
YR 2012
FD 2012-11
LK http://hdl.handle.net/10498/20256
UL http://hdl.handle.net/10498/20256
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026