RT journal article
T1 SAR studies of epoxycurcuphenol derivatives on leukemia CT-CD4 cells
A1 G. Galindo, José L.
A1 Macías, Mariola
A1 González Molinillo, José María
A1 Muñoz-Suano, Alba
A1 Torres Martínez, Ascensión
A1 Varela Montoya, Rosa María
A1 García Cózar, Francisco José
A1 Macías Domínguez, Francisco Antonio
A2 Química Orgánica
K1 antiproliferative bioassay
K1 leukemia cells
K1 Sunflower
K1 Helianthus annuus
K1 Epoxycurcuphenol derivatives
K1 SAR studies
AB Bioactive natural products are a potential source of new pharmaceuticals since they offer new modes ofaction and more specific activities. The use of derivatization also enables the optimal structure for theirbiological activity to be determined. In this study several epoxycurcuphenol derivatives were synthesized.The substitution pattern on the aromatic and oxirane rings was varied along with that at the benzylicposition and the length of the side chain was altered. These changes were made in order to gain adeeper understanding of the structural requirements for activity. The biological activities of these compoundswere evaluated on the human leukemia cell line Jurkat using an antiproliferative assay. The activityresults and structural requirements are discussed.
PB Bioorganic & Medicinal Chemistry
YR 2012
FD 2012-09
LK http://hdl.handle.net/10498/20258
UL http://hdl.handle.net/10498/20258
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026