RT journal article
T1 Soil biodegradation of a benzoxazinone analog proposed as a natural products-based herbicide
A1 Oliveros-Bastidas, Alberto
A1 Chinchilla Salcedo, Nuria
A1 Marín Sánchez, David
A1 González Molinillo, José María
A1 Macías Domínguez, Francisco Antonio
A2 Química Orgánica
K1 D-DIBOA
K1 benzoxazinones
K1 degradation study
K1 soil
K1 herbicide models
AB Aims Benzoxazinones with the 4-hydroxy-(2H)-1,4- benzoxazin-3(4H)-one skeleton have been proposed as potentially successful models for the development of novel design leads. D-DIBOA has proven to be the most promising base structure in the search for novel herbicide models based on the benzoxazinone skeleton. Thebiodegradation dynamics of D-DIBOA in soil are therefore relevant and are the subject of this study. Methods A previously optimized methodology for the assessment of biodegradation has been applied for the first time to a synthetic benzoxazinone. Results Biodegradability is a characteristic of natural benzoxazinones and a safety requirement for the development of herbicidal chemicals. The biodegradation phenomenon and its consequences for the development of new herbicide models are discussed. The half-life determined for D-DIBOA was much higher than those previously reported for the natural products DIBOA, DIMBOA and their benzoxazolinone derivatives. Conclusions This finding, together with its previously described potent phytotoxicity, suggests that D-DIBOA is a useful candidate for novel herbicide model development. The lactam D-HBOA, which is slightly less phytotoxic than its precursor, was discovered to be the first and principal metabolite resulting from D-DIBOA degradation.
PB Plant Soil
YR 2015
FD 2015-04
LK http://hdl.handle.net/10498/20318
UL http://hdl.handle.net/10498/20318
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026