RT journal article
T1 Trends in the Synthesis and Functionalization of Guaianolides
A1 Santana, Alejandro
A1 González Molinillo, José María
A1 Macías Domínguez, Francisco Antonio
A2 Química Orgánica
K1 total synthesis
K1 natural products
K1 terpenoids
K1 lactones
K1 guaianolides
AB Guaianolides constitute a large and diverse group of biologically active sesquiterpenes. Guaianolide and seco-guaianolides can also be used as, for example, scaffolds for the development of new active molecules that are readily accessible by synthetic methods. Nevertheless, these lactones often have complex structures that make their synthesis difficult. The aim of this microreview is to provide an overview of the developments in guaianolide synthesis by the two major synthetic strategies: semi-synthesis and total synthesis. Partial and total syntheses of guaianolides are described, with particular emphasis placed on the methods reported in the last decade. The methods discussed include rearrangements, cycloadditions, ring-closing metathesis, the use of transitionmetal catalysts, photochemical reactions, and other recently developed techniques as key steps.
PB European Journal of Organic Chemistry
YR 2015
FD 2015-01
LK http://hdl.handle.net/10498/20321
UL http://hdl.handle.net/10498/20321
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026