RT journal article
T1 Phthalimide-derived strigolactone mimics as germinating agents for seeds of parasitic weeds
A1 Ghooray, Kala
A1 Fernández-Aparicio, Mónica
A1 Cala Peralta, Antonio
A1 González Molinillo, José María
A1 García Galindo, Juan Carlos
A1 Rubiales Bonilla, Diego
A1 Macías Domínguez, Francisco Antonio
A2 Química Orgánica
K1 broomrape
K1 seed germination
K1 strigolactone
K1 phthalimide
K1 butenolide
K1 GR24
AB Broomrapes attack important crops, cause severe yield losses and are difficult to eliminate because their seed bank is virtually indestructible. In the absence of a host, the induction of seed germination leads to inevitable death due tonutrient starvation. Synthetic analogues ofgermination-inducing factorsmay constitute a cheap and feasible strategy to control the seed bank. These compounds should be easy and cheap to synthesise, as this will allow their mass production. The aim of this work is to obtain new synthethic germinating agents.Nineteen N-substituted phthalimides containing a butenolide ring and different substituents in the aromatic ringwere synthesised. The synthesis started with commercially available phthalimides. The complete collection was assayed against the parasitic weeds Orobanche minor, O. cumana, Phelipanche ramosa and P. aegyptiaca, with the synthetic strigolactone analogue GR24 used as a positive control. These compounds offered low EC50 values: O. cumana 38.3 𝝁M, O. minor 3.77 𝝁M, P. aegyptiaca 1.35 𝝁Mand P. ramosa 1.49 𝝁M.The synthesiswas carried out in a fewsteps and provided the target compounds in good yields. The compoundstested showed great selectivity, and low EC50 values were obtained for structures that were simpler than GR24.
PB Willey
YR 2016
FD 2016-06
LK http://hdl.handle.net/10498/20347
UL http://hdl.handle.net/10498/20347
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026