RT journal article
T1 Synthesis, antibacterial and antifungal activities of naphthoquinone derivatives: a structure–activity relationship study
A1 Sánchez Calvo, Juan Manuel
A1 R. Barbero, Gara
A1 Guerrero Vásquez, Guillermo A
A1 García Durán, Alexandra
A1 Macías, Mariola
A1 Rodríguez Iglesias, Manuel Antonio
A1 González Molinillo, José María
A1 Macías Domínguez, Francisco Antonio
A2 Anatomía PatológicaBiología Celular, Histología, Historia de la Ciencia, Medicina Legal...
A2 Química Orgánica
K1 napthoquinone
K1 antifungal
K1 antibacterial
K1 minimum inhibitory concentration
K1 Structure–activity relationship
AB The synthesis of 1,4-naphthoquinone derivatives is of great interest since these compounds exhibit strong activity as antimalarial, antibacterial, antifungal and anticancer agents. A series of 50 naphthoquinone derivatives was synthesized and evaluated for antibacterial and antifungal activity against Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, Candida krusei, Candida parapsilosis and Cryptococcus neoformans using the broth microdilution method. The Candida species were the most susceptible microorganisms. Halogen derivatives of 1,4-naphthoquinone presented strong activity, e.g., 2-bromo-5-hydroxy-1,4-naphthoquinone, which exhibited inhibition at an MIC of 16 lg/ mL in S. aureus, and 2-chloro-5,8-dihydroxy-1,4-naphthoquinone, with an MIC of 2 lg/mL in C. krusei. These compounds showed higher activity against fungi, but the antibacterial activities were very low. The study of structure–activity relationships is very important in the search for new antimicrobial drugs due to the limited therapeutic arsenal.
PB Medicinal Chemistry Research
SN 1054-2523
YR 2016
FD 2016-04
LK http://hdl.handle.net/10498/20350
UL http://hdl.handle.net/10498/20350
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026