RT journal article
T1 The Algal Meroterpene 11-Hydroxy-11-O-Methylamentadione Ameloriates Dextran Sulfate Sodium-Induced Colitis in Mice
A1 Zbakh, Hanna
A1 Talero, Elena
A1 Avila, Javier
A1 Alcaide, Antonio
A1 Motilva, Virginia
A1 Reyes Jiménez, Carolina de los
A1 Zubía Mendoza, Eva
A2 Química Orgánica
K1 marine meroterpenoids
K1 macroalgae
K1 intestinal inflammation
K1 experimental colitis
K1 cytokines
K1 COX-2
K1 iNOS
AB Inflammatory bowel disease (IBD) is a complex class of immune disorders. Unfortunately, a treatment for total remission has not yet been found, while the use of natural product-based therapies has emerged as a promising intervention. The present study was aimed to investigate the anti-inflammatory effects of the algal meroterpene 11-hydroxy-11-O-methylamentadione (AMT-E) in a murine model of dextran sodium sulphate (DSS)-induced colitis. AMT-E was orally administered daily (1, 10, and 20 mg/kg animal) to DSS treated mice (3% w/v) for 7 days. AMT-E prevented body weight loss and colon shortening and effectively attenuated the extent of the colonic damage.Similarly, AMT-E increased mucus production and reduced myeloperoxidase activity (marker for anti-inflammatory activity). Moreover, the algal meroterpene decreased the tumor necrosis factor (TNF)- , interleukin (IL)-1 , and IL-10 levels, and caused a significant reduction of the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Our results demonstrate the protective effects of AMT-E on experimental colitis, provide an insight of the underlying mechanisms of this compound, and suggest that this class of marine natural products might be an interesting candidate for further studies on the prevention/treatment of IBD.
PB MDPI
YR 2016
FD 2016-08
LK http://hdl.handle.net/10498/20365
UL http://hdl.handle.net/10498/20365
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 22-sep-2026