RT journal article
T1 DoE (Design of Experiments) Assisted Allylic Hydroxylation of Enones Catalysed by a Copper–Aluminium Mixed Oxide
A1 García-Cabeza, Ana Leticia
A1 Marín Barrios, Rubén
A1 Azarken, Redouan
A1 Moreno Dorado, Francisco Javier
A1 Vidal Muñoz, Hilario
A1 M. Guerra, Francisco
A1 Ortega Agüera, María Jesús
A1 Gatica Casas, José Manuel
A1 Martínez Massanet, Guillermo
A2 Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica
A2 Química Orgánica
K1 oxidation
K1 C-H activation
K1 heterogeneous catalysis
K1 enones
AB The allylic hydroxylation of enones using dioxygen as the oxidant has been studied. The reaction was first examined in the absence of any catalyst, using β-ionone as a model substrate. Then a new copper–aluminium mixed oxide, Cu–Al Ox, was prepared and characterized in order to be used as a catalyst. This oxide showed good activity, and provided the corresponding γ- or ε-hydroxylated enones, starting from different α,β- or α,β,γ,δ-unsaturated ketones. In all cases, the yields were significantly improved compared to experiments run in the absence of the catalyst. The reaction was selective, and the formation of epoxides or other overoxidation products was detected only to a minor extent. The described procedure is a technically straightforward synthetic alternative to those methods described to date involving many reaction steps or toxic reagents. The reactions were optimized using design of experiments techniques (DoE).
PB Willey
YR 2013
FD 2013-10
LK http://hdl.handle.net/10498/20366
UL http://hdl.handle.net/10498/20366
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026