RT journal article
T1 Optimization by Response Surface Methodology (RSM) of the Kharasch−Sosnovsky Oxidation of Valencene
A1 García-Cabeza, Ana Leticia
A1 P. Ray, Lindsey
A1 Marín Barrios, Rubén
A1 Moreno Dorado, Francisco Javier
A1 Guerra, Francisco M.
A1 Ortega Agüera, María Jesús
A1 Martínez Massanet, Guillermo
A2 Química Orgánica
AB Response surface methodology (RSM) has been employed to model and optimize the Kharasch−Sosnovskyallylic oxidation of valencene. The detailed effects of the amounts of oxidant, substrate, copper catalyst, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), and temperature have been studied. The concentration of substrate and quantity of oxidant have been determined as the most significant variables. The interaction effects on the yield have been investigated using a three-level full-factorial design. The yield of benzoyloxyvalencene has been improved to 99%. Analysis of variance (ANOVA) has been used to evaluate the goodness of fit of the model.
PB ACS Publications
YR 2015
FD 2015-09
LK http://hdl.handle.net/10498/20370
UL http://hdl.handle.net/10498/20370
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026