RT journal article T1 Oxidative stress biomarkers in Senegal sole, Solea senegalensis, to assess the impact of heavy metal pollution in a Huelva estuary (SW Spain): Seasonal and spatial variation A1 Gravato, Carlos A1 Guilhermino, Lucia A1 Galindo Riaño, María Dolores A1 Oliva Ramírez, Milagrosa A1 Vicente Martorell, Juan José A2 Biología A2 Química Analítica K1 Oxidative stress K1 Biomarkers K1 Heavy metals K1 Solea senegalensis AB The responseofwildfishtoheavymetalswasstudiedinsole(Solea senegalensis) collectedin2004, 2005 and 2006 at three sampling sites from Huelva estuary (SWSpain), in the vicinity of a petrochemical and mining industry. Heavy metals As, Cd, Cu, Fe, Pb and Zn were analyzed in samples collected from sediment, water and tissue (liver) to examine their bioconcentration and effects in fish such as lipid peroxidation (LPO), catalase (CAT;EC1.11.1.6), glutathione peroxidase (GPx; EC1.8.1.7), glutathione S-transferase (GST;EC2.5.1.18) and glutathione reductase (GR;EC1.11.1.6) were also analyzed in the fish liver.The results showed different effects in sole from diverse locations with varying degrees of pollution. Significant differences in LPO, CAT and GR activities between control fish and fish from sampling sites were observed as well as seasonal differences for biomarkers. Significant correlations were established between some biomarkers and heavy metals concentrations in liver, sediment and water. This study indicates the usefulness of integrating a set of biomarkers to assess the effects of pollutants in aquatic environments under complex mix of pollutants and chronic pollution situation. PB Elsevier YR 2012 FD 2012-01 LK http://hdl.handle.net/10498/20394 UL http://hdl.handle.net/10498/20394 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 13-nov-2026