RT journal article
T1 Multivariate optimization of the KharascheSosnovsky allylic oxidation of olefins
A1 Marín Barrios, Rubén
A1 Guerra, Francisco M.
A1 García-Cabeza, Ana Leticia
A1 Moreno Dorado, Francisco Javier
A1 Martínez Massanet, Guillermo
A2 Química Orgánica
K1 allylic oxidation
K1 olefins
K1 kharasch-sosnovsky reaction
K1 simplex
K1 multivariate optimization
AB The multivariate optimization method known as simplex is applied to the KharascheSosnovsky allylic oxidation of double bonds. By applying this method, the amounts of three variables (copper source, oxidant, and additive) are optimized at the same time. Under the conditions thus obtained the reaction takes place in a considerable shorter time, being the alkene the limiting reagent. These conditions are applied to some monoterpenes and sesquiterpenes leading regioselectively to the corresponding benzoate esters, opening a route to the employment of this reaction in the synthesis of more complex molecules.
PB Tetrahedron
YR 2012
FD 2012-01
LK http://hdl.handle.net/10498/20503
UL http://hdl.handle.net/10498/20503
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 15-nov-2026