RT journal article
T1 Chemical genetics strategies for identification of molecular targets
A1 Botubol Ares, José Manuel
A1 Durán Peña, María Jesús
A1 Hernández Galán, Rosario
A1 González Collado, Isidro
A2 Química Orgánica
K1 Chemical biology
K1 Forward chemical genetics
K1 Small molecules
K1 Target proteins
AB Chemical genetics is an emerging field that can be used to study the interactions of chemical compounds, including natural products, with proteins. Usually, the identification of molecular targets is the starting point for studying a drug’s mechanism of action and this has been a crucial step in understanding many biological processes. While a great variety of target identification methods have been developed over the last several years, there are still many bioactive compounds whose target proteins have not yet been revealed because no routine protocols can be adopted. This review contains information concerning the most relevant principles of chemical genetics with special emphasis on the different genomic and proteomic approaches used in forward chemical genetics to identify the molecular targets of the bioactive compounds, the advantages and disadvantages of each and a detailed list of successful examplesof molecular targets identified with these approaches.
PB Springuer
YR 2013
FD 2013
LK http://hdl.handle.net/10498/20547
UL http://hdl.handle.net/10498/20547
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026