RT journal article
T1 Stereoselective Synthesis and Absolute Configuration Determination of Xylariolide A
A1 Botubol Ares, José Manuel
A1 Macías Sánchez, Antonio José
A1 González Collado, Isidro
A1 Hernández Galán, Rosario
A2 Química Orgánica
K1 Natural products
K1 Total synthesis
K1 Asymmetric synthesis
K1 Configuration determination
K1 Medicinal chemistry
K1 Lactones
AB The asymmetric synthesis of the antibacterial and antitumoral natural compound xylariolide A (1) and five stereoisomers has been achieved. The strategy is based on the onepot epoxidation/lactonisation or dihydroxylation/lactonisation of the hypothetical biosynthetic intermediate xylarioic A acid (8). The absolute configuration of xylariolide A was thus determined to be 3R,4S,5R,1 R,2 R after the synthesis of 1, two epimers, i.e., 1 -epi-xylariolide A (3) and 2 -epi-xylariolide A (4), and three more diastereoisomers 5–7.
PB Willey
YR 2013
FD 2013
LK http://hdl.handle.net/10498/20572
UL http://hdl.handle.net/10498/20572
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026