RT journal article
T1 Exploring mutasynthesis to increase structural diversity in the synthesis of highly oxygenated polyketide lactones
A1 Botubol Ares, José Manuel
A1 Durán Peña, María Jesús
A1 Macías Sánchez, Antonio José
A1 Hanson, J. R.
A1 González Collado, Isidro
A1 Hernández Galán, Rosario
A2 Química Orgánica
AB The enantioselective synthesis of (2R,3R,4E,8E)-3-hydroxy-2,4,8-trimethyldeca-4,8-dienolide (5) byring-closing metathesis is described. This compound is an analogue of 3,4-dihydroxy-2,4,6,8-tetramethyldec-8-enolide (4) which is a rare 11-membered lactone produced by the fungus, Botrytis cinerea.Mutasynthetic studies with compound 5 using two mutants of B. cinerea led to the isolation of four newhighly oxygenated 11-membered lactones (11–14) in which compound 5 has been stereoselectivelyepoxidized and hydroxylated at sites that were not easily accessible by classical synthetic chemistry.
PB The Royal Society of Chemistry
YR 2014
FD 2014
LK http://hdl.handle.net/10498/20576
UL http://hdl.handle.net/10498/20576
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026