RT journal article
T1 The Asymmetric Total Synthesis of Cinbotolide: A Revision of the Original Structure
A1 Botubol Ares, José Manuel
A1 Durán Peña, María Jesús
A1 Macías Sánchez, Antonio José
A1 R. Hanson, James
A1 González Collado, Isidro
A1 Hernández Galán, Rosario
A2 Química Orgánica
AB The structure 3,4-dihydroxy-2,4,6,8-tetramethyldec-8-enolide (1) was assigned to a metabolite of Botrytis cinerea, but the spectra of several synthetic analogues had significant differences from that of 1. Examination of the constituents of a B. cinerea mutant that overproduces polyketides gave sufficient quantities of 1, now named cinbotolide, for chemical transformations. These led to a revised γ-butyrolactone structure for the metabolite. This structure has been confirmed by an asymmetric total synthesis, which also established its absolute configuration.
PB ACS Publications
YR 2014
FD 2014-11
LK http://hdl.handle.net/10498/20578
UL http://hdl.handle.net/10498/20578
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026