RT journal article
T1 Diastereoselective and enantioselective preparation of nor-mevaldic acid surrogates through desymmetrisation methodology. Enantioselective synthesis of (+) and (-) nor-mevalonic lactones
A1 Botubol Ares, José Manuel
A1 Durán Peña, María Jesús
A1 Hernández Galán, Rosario
A1 González Collado, Isidro
A1 M. Harwood, Laurence
A1 Macías Sánchez, Antonio José
A2 Química Orgánica
K1 Botrytis cinerea
K1 Desymmetrisation
K1 meso-Dialdehyde
K1 Nor-methyl mevaldate
AB Solvent-free desymmetrisation of a meso-dialdehyde with chiral alcohols, led to preparation of 4- silyloxy-6-alkyloxytetrahydro-2H-pyran-2-one derivatives with a 96% de. This methodology, which yields the corresponding methyl nor-mevaldates with 99% ee, has been applied to the enantioselective synthesis of the ( )-(R) and (þ)-(S) nor-mevalonic acid lactones.
PB Elsevier
YR 2015
FD 2015
LK http://hdl.handle.net/10498/20582
UL http://hdl.handle.net/10498/20582
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026