RT journal article
T1 Multiple Anticancer Effects of Damsin and Coronopilin Isolated from Ambrosia arborescens on Cell Cultures
A1 Villagomez, Rodrigo
A1 C. Rodrigo, Gloria
A1 González Collado, Isidro
A1 A. Calzado, Marco
A1 Muñoz, Eduardo
A1 Åkesson, Björn
A1 Sterner, Olov
A1 R. Almanza, Giovanna
A1 Duan, Rui-Dong
A2 Química Orgánica
K1 Ambrosia arborescens
K1 damsin
K1 coronopilin
K1 chemoselective bromination
K1 sesquiterpenes
K1 cell proliferation
K1 STAT3
K1 NF-κB
K1 apoptosis
AB Terpenoids in plants are important sources for drug discovery. In this study, we extracted damsin and coronopilin, two sesquiterpene lactones, from Ambrosia arborescens and examined their anticancer effects on cell cultures. Damsin and coronopilin inhibited cell proliferation, DNA biosynthesis and formation of cytoplasmic DNA histone complexes in Caco-2 cells, with damsin being more potent than coronopilin. Further studies using the luciferase reporter system showed that damsin and coronopilin also inhibited expressions of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription-3 (STAT3), indicating that these sesquiterpenes can interfere with NF- κB and STAT3 pathways. Finally, we examined the effects of two synthetic dibrominated derivatives of damsin, 11α,13- dibromodamsin and 11β,13-dibromodamsin. While bromination appeared to weaken the antiproliferative effectsof damsin, the β epimer had strong inhibitory effects on STAT3 activation. In conclusion, the sesquiterpene lactonesdamsin and coronopilin have inhibitory effects on cell proliferation, DNA biosynthesis and NF-κB and STAT3pathways, thus being potentially important for discovery of drugs against cancer.
PB The International Institute of Anticancer Research
YR 2013
FD 2013
LK http://hdl.handle.net/10498/20585
UL http://hdl.handle.net/10498/20585
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026