RT journal article
T1 nor-Mevaldic acid surrogates as selective antifungal agent leads against Botrytis cinerea. Enantioselective preparation of 4-hydroxy-6-(1-phenylethoxy)tetrahydro-2H-pyran-2-one
A1 Botubol Ares, José Manuel
A1 Durán Peña, María Jesús
A1 Hernández Galán, Rosario
A1 González Collado, Isidro
A1 M. Harwood, Laurence
A1 Macías Sánchez, Antonio José
A2 Química Orgánica
K1 Antifungal agents
K1 Desymmetrisation
K1 Lactones
K1 nor-Methyl mevaldate
K1 Statins
AB Solvent-free desymmetrisation of meso-dialdehyde 1 with chiral 1-phenylethan-1-ol, led to preparation of 4-silyloxy-6-alkyloxytetrahydro-2H-pyran-2-one (+)-3a with a 96:4 dr Deprotected lactone (+)-19a and the related racemic lactones 16a–18a present a lactone moiety resembling the natural substrate of HMG-CoA reductase and their antifungal properties have been evaluated against the phytopathogenic fungi Botrytis cinerea and Colletotrichum gloeosporioides. These compounds were selectively active against B. cinerea, while inactive against C. gloeosporioides.
PB Elsevier
YR 2015
FD 2015
LK http://hdl.handle.net/10498/20586
UL http://hdl.handle.net/10498/20586
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026