RT journal article
T1 Unexpected Mild Protection of Alcohols as 2-O-THF and 2-O-THP Ethers Catalysed by Cp2TiCl Reveal an Intriguing Role of the Solvent in the Single- Electron Transfer Reaction
A1 Durán Peña, María Jesús
A1 Botubol Ares, José Manuel
A1 R. Hanson, James
A1 Hernández Galán, Rosario
A1 González Collado, Isidro
A2 Química Orgánica
K1 Homogeneous catalysis
K1 Titanium
K1 Radical reactions
K1 Alcohols
K1 Protecting groups
AB A method for the conversion of primary, secondary and tertiary alcohols into the corresponding THF ethers at room temperature and primary and secondary alcohols into the corresponding THP ethers, has been developed using titanium(III) species generated from a catalytic amount of titanocene dichloride or (4R,5R)-(–)-2,2-dimethyl-α,α,α ,α -tetra(1-naphth-yl)-1,3-dioxolane-4,5-dimethanolatotitanium(IV) dichloride: acetonitrile adduct together with manganese(0) as a reductant and bromoform in THF or THP as the solvent. A radical mechanism is proposed for this transformation revealing an intriguing role of the solvent in the single-electron transfer reactions catalysed by the low valent TiIII system.
YR 2015
FD 2015
LK http://hdl.handle.net/10498/20590
UL http://hdl.handle.net/10498/20590
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026