RT journal article
T1 Overeating, caloric restriction and breast cancer risk by pathologic subtype: the EPIGEICAM study
A1 Lope, Virginia
A1 Martín, Miguel
A1 Castelló, Adela
A1 Ruiz, Amparo
A1 Casas, Ana Mª
A1 Baena Cañada, José Manuel
A1 Antolín, Silvia
A1 Ramos-Vázquez, Manuel
A1 García-Sáenz, José Ángel
A1 Muñoz, Montserrat
A1 Lluch, Ana
A1 de Juan-Ferré, Ana
A1 Jara, Carlos
A1 Sánchez-Rovira, Pedro
A1 Antón, Antonio
A1 Chacón, José Ignacio
A1 Arcusa, Angels
A1 Jimeno, Mª Angeles
A1 Bezares, Susana
A1 Vioque, Jesús
A1 Carrasco, Eva
A1 Pérez-Gómez, Beatriz
A1 Pollán, Marina
A2 Medicina
A2 Medicina
AB This study analyzes the association of excessive energy intake and caloric restriction with breastcancer (BC) risk taking into account the individual energy needs of Spanish women. We conducteda multicenter matched case-control study where 973 pairs completed lifestyle and food frequencyquestionnaires. Expected caloric intake was predicted from a linear regression model in controls,including calories consumed as dependent variable, basal metabolic rate as an offset and physicalactivity as explanatory. Overeating and caloric restriction were defined taking into account the 99%confidence interval of the predicted value. The association with BC risk, overall and by pathologicsubtype, was evaluated using conditional and multinomial logistic regression models. Whilepremenopausal women that consumed few calories (>20% below predicted) had lower BC risk(OR = 0.36; 95% CI = 0.21–0.63), postmenopausal women with an excessive intake (≥40% abovepredicted) showed an increased risk (OR = 2.81; 95% CI = 1.65–4.79). For every 20% increase in relative(observed/predicted) caloric intake the risk of hormone receptor positive (p-trend < 0.001) and HER2+(p-trend = 0.015) tumours increased 13%, being this figure 7% for triple negative tumours. While highenergy intake increases BC risk, caloric restriction could be protective. Moderate caloric restriction, incombination with regular physical activity, could be a good strategy for BC prevention.
PB Nature
SN 2045-2322
YR 2019
FD 2019-03
LK http://hdl.handle.net/10498/21297
UL http://hdl.handle.net/10498/21297
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026