RT journal article
T1 Protein Kinase C: Targets to Regenerate Brain Injuries?
A1 Geribaldi Doldán, Noelia
A1 Gómez Oliva, Ricardo
A1 Domínguez García, Samuel
A1 Nunez Abades, Pedro
A1 Castro González, Carmen
A2 Bioquímica y Biología MolecularMicrobiología, Medicina Preventiva, Salud Pública
K1 protein kinase C
K1 neurogenesis
K1 ADAM17/TACE
K1 brain injury
K1 neuroregeneration
AB Acute or chronic injury to the central nervous system (CNS), causes neuronal deathand irreversible cognitive deficits or sensory-motor alteration. Despite the capacityof the adult CNS to generate new neurons from neural stem cells (NSC), neuronalreplacement following an injury is a restricted process, which does not naturally resultin functional regeneration. Therefore, potentiating endogenous neurogenesis is oneof the strategies that are currently being under study to regenerate damaged braintissue. The insignificant neurogenesis that occurs in CNS injuries is a consequenceof the gliogenic/non-neurogenic environment that inflammatory signaling moleculescreate within the injured area. The modification of the extracellular signals to generatea neurogenic environment would facilitate neuronal replacement. However, in orderto generate this environment, it is necessary to unearth which molecules promote orimpair neurogenesis to introduce the first and/or eliminate the latter. Specific isozymesof the protein kinase C (PKC) family differentially contribute to generate a gliogenicor neurogenic environment in injuries by regulating the ADAM17 mediated releaseof growth factor receptor ligands. Recent reports describe several non-tumorigenicditerpenes isolated from plants of the Euphorbia genus, which specifically modulate theactivity of PKC isozymes promoting neurogenesis. Diterpenes with 12-deoxyphorbolor lathyrane skeleton, increase NPC proliferation in neurogenic niches in the adultmouse brain in a PKCb dependent manner exerting their effects on transit amplifyingcells, whereas PKC inhibition in injuries promotes neurogenesis. Thus, compounds thatbalance PKC activity in injuries might be of use in the development of new drugs andtherapeutic strategies to regenerate brain injuries.
PB FRONTIERS MEDIA SA
SN 2296-634X
YR 2019
FD 2019-03
LK http://hdl.handle.net/10498/21319
UL http://hdl.handle.net/10498/21319
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026