RT journal article T1 The Gonadotropin-Inhibitory Hormone: What We Know and What We Still Have to Learn From Fish A1 Di Yorio, María P. A1 Muñoz-Cueto, José Antonio A1 Paullada Salmerón, José Antonio A1 Somoza, Gustavo M. A1 Tsutsui, Kazuyoshi A1 Vissio, Paula G. A2 Biología K1 GnIH K1 fish K1 brain K1 ontogeny K1 GnRH K1 growth K1 reproduction AB Gonadotropin-inhibitory hormone, GnIH, is named because of its function in birds andmammals; however, in other vertebrates this function is not yet clearly established.More than half of the vertebrate species are teleosts. This group is characterized bythe 3R whole genome duplication, a fact that could have been responsible for the greatphenotypic complexity and great variability in reproductive strategies and sexual behavior.In this context, we revise GnIH cell bodies and fibers distribution in adult brains of teleosts,discuss its relationship with GnRH variants and summarize the few reports availableabout the ontogeny of the GnIH system. Considering all the information presented in thisreview, we propose that in teleosts, GnIH could have other functions beyond reproductionor act as an integrative signal in the reproductive process. However, further studies arerequired in order to clarify the role of GnIH in this group including its involvement indevelopment, a key stage that strongly impacts on adult life. PB FRONTIERS MEDIA SA SN 1664-2392 YR 2019 FD 2019-02 LK http://hdl.handle.net/10498/21326 UL http://hdl.handle.net/10498/21326 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 08-nov-2026