RT journal article
T1 Description of the BRIGHTLIGHT cohort: the evaluation of teenage and young adult cancer services in England
A1 Taylor, Rachel M.
A1 Fern, Lorna A.
A1 Barber, Julie
A1 Álvarez Gálvez, Javier
A1 Feltbower, Richard
A1 Morris, Stephen
A1 Hooker, Louise
A1 McCabe, Martin G.
A1 Gibson, Faith
A1 Raine, Rosalind
A1 Stark, Dan P.
A1 Whelan, Jeremy S.
A2 Bioquímica y Biología MolecularMicrobiología, Medicina Preventiva, Salud Pública
AB Objective International recognition of the unique needsof young people with cancer is growing. Many countrieshave developed specialist age-appropriate cancer servicesbelieving them to be of value. In England, 13 specialistprincipal treatment centres (PTCs) deliver cancer care toyoung people. Despite this expansion of specialist care,systematic investigation of associated outcomes andcosts has, to date, been lacking. The aim of this paper isto describe recruitment and baseline characteristics of theBRIGHTLIGHT cohort and the development of the bespokemeasures of levels of care and disease severity, which willinform the evaluation of cancer services in England.Design Prospective, longitudinal, observational study.Setting Ninety-seven National Health Service hospitals inEngland.Participants A total of 1114 participants were recruited anddiagnosed between July 2012 and December 2014: 55%(n=618) were men, mean age was 20.1 years (SD=3.3),most (86%) were white and most common diagnoses werelymphoma (31%), germ cell tumour (19%) and leukaemia(13%).Results At diagnosis, median quality of life score wassignificantly lower than a published control threshold (69.7points); 40% had borderline to severe anxiety, and 21%had borderline to severe depression. There was minimalvariation in other patient-reported outcomes according toage, diagnosis or severity of illness. Survival was lower inthe cohort than for young people diagnosed during the sameperiod who were not recruited (cumulative survival probability4 years after diagnosis: 88% vs 92%).Conclusions Data collection was completed in March 2018.Longitudinal comparisons will determine outcomes and costsassociated with access/exposure to PTCs. Findings will informinternational intervention and policy initiatives to improveoutcomes for young people with cancer.
PB BMJ PUBLISHING GROUP
SN 2044-6055
YR 2019
FD 2019-06
LK http://hdl.handle.net/10498/21468
UL http://hdl.handle.net/10498/21468
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 11-nov-2026