RT journal article T1 Effectiveness of a muticomponent workout program integrated in an evidence based multimodal program in hyperfrail elderly patients: POWERAGING randomized clinical trial protocol A1 Gonzalez-Sanchez, Manuel A1 Cuesta-Vargas, Antonio Ignacio A1 Rodriguez Gonzalez, María del Mar A1 Diaz Caro, Elvira A1 Ortega Nunez, German A1 Galán Mercant, Alejandro A1 Bedoya Belmonte, Juan José A2 Enfermería y Fisioterapia K1 Frailty K1 Physical activity K1 Physical fitness K1 Falls K1 Diet K1 Elderly AB BackgroundShort-term and mid-term comparison of the efficacy of a multimodal program that incorporates a therapeutic workout program, medication review, diet adjustment and health education, in comparison to the standard medical practice in the improvement of the neuromuscular and physiological condition. Furthermore, it is intended to analyse the maintenance of these effects in a long-term follow-up (12months) from the onset of the intervention.MethodsA randomized clinical trial of elderly frail patients drawn from the Clinical Management Unit Tiro de Pichon, Health District of Malaga, will be included in the study (after meeting the inclusion / exclusion criteria) will be randomized in two groups: a control group that will undergo an intervention consistent of medication review + diet adjustment + health education (regular workout recommendations within a complete advice on healthy lifestyles) and an experimental group whose intervention will consist of a multimodal treatment: therapeutic workout program+ medication review+ diet adjustment + health education. The sociodemographic, clinical and tracing variables will be reflected at the beginning of the study. In addition, the follow-up variables will be gathered at the second and sixth months after the beginning of the treatment and at the third and sixth months after the treatment (follow-up). The follow-up variables that will be measured are: body mass index, general health condition, fatigue, frailty, motor control, attention- concentration- memory, motor memory, spatial orientation, grip strength, balance (static, semi-dynamic), gait speed and metabolomics.A descriptive analysis of the sociodemographic variables of the participants will be conducted. One-Factor ANOVA will be used for the Within-Subject analysis and as for the Between-Subject analysis, the outcome variables between both the groups in each moment of the data collection will be compared.DiscussionA multimodal program that incorporates a therapeutic workout program, medication review, diet adjustment and health education may be effective treatment to reduce the functional decline in elderly. The results of the study will provide information on the possible strengths and benefits in multimodal program in elderly.Trial registrationClinicalTrials.gov NCT02772952 registered May 2017 PB BMC SN 1471-2318 YR 2019 FD 2019-06 LK http://hdl.handle.net/10498/21593 UL http://hdl.handle.net/10498/21593 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 21-sep-2026