RT journal article
T1 Antiretroviral therapy partially improves the abnormalities of dendritic cells and lymphoid and myeloid regulatory populations in recently infected HIV patients
A1 Márquez Coello, María De Las Mercedes
A1 Montes de Oca Arjona, Montserrat
A1 Martín Aspas, Andrés
A1 Guerrero Sánchez, Francisca
A1 Fernández-Gutiérrez del Álamo, Clotilde
A1 Girón González, José Antonio
A2 Bioquímica y Biología MolecularMicrobiología, Medicina Preventiva, Salud Pública
A2 Medicina
A2 Medicina
AB This study aimed to evaluate the effects of antiretroviral therapy on plasmacytoid (pDC) and myeloid(mDC) dendritic cells as well as regulatory T (Treg) and myeloid-derived suppressor (MDSC) cells in HIVinfectedpatients. Forty-five HIV-infected patients (20 of them with detectable HIV load −10 recentlyinfected and 10 chronically infected patients-, at baseline and after antiretroviral therapy, and 25 withundetectable viral loads) and 20 healthy controls were studied. The influence of HIV load, bacterialtranslocation (measured by 16S rDNA and lipopolysaccharide-binding protein) and immune activationmarkers (interleukin –IL- 6, soluble CD14, activated T cells) was analyzed. The absolute numbers andpercentages of pDC and mDC were significantly increased in patients. Patients with detectable viralload exhibited increased intracellular expression of IL-12 by mDCs and interferon -IFN- α by pDCs.Activated population markers were elevated, and the proportion of Tregs was significantly higher inHIV-infected patients. The MDSC percentage was similar in patients and controls, but the intracellularexpression of IL-10 was significantly higher in patients. The achievement of undetectable HIV loadafter therapy did not modify bacterial translocation parameters, but induce an increase in pDCs, mDCsand MDSCs only in recently infected patients. Our data support the importance of early antiretroviraltherapy to preserve dendritic and regulatory cell function in HIV-infected individuals.
PB NATURE PUBLISHING GROUP
SN 2045-2322
YR 2019
FD 2019-08
LK http://hdl.handle.net/10498/21715
UL http://hdl.handle.net/10498/21715
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 14-nov-2026