RT journal article
T1 Left Ventricular Dysfunction and Plasmatic NT-proBNP Are Associated with Adverse Evolution in Respiratory Syncytial Virus Bronchiolitis
A1 Rodriguez Gonzalez, Moises
A1 Perez Reviriego, Alvaro Antonio
A1 Castellano Martinez, Ana
A1 Lubián López, Simón Pedro
A1 Benavente Fernández, Isabel
A2 Materno-Infantil y Radiología
K1 respiratory syncytial virus
K1 NT-proBNP
K1 echocardiography
K1 pulmonary hypertension
K1 myocardial dysfunction
K1 tissue doppler imaging
K1 Tei index
K1 biomarkers
K1 infants
AB Aim: To investigate whether the presence of left ventricular myocardial dysfunction(LVMD) assessed by Tei index (LVTX) impacts the outcomes of healthy infants with RespiratorySyncytial Virus Bronchiolitis (RSVB). To explore whether N-terminal pro-B-type natriuretic peptide(NT-proBNP) increases the accuracy of traditional clinical markers in predicting the outcomes.Methods: A single-centre, prospective, cohort study including healthy infants aged 1–12 monthsold admitted for RSVB between 1 October 2016 and 1 April 2017. All patients underwent clinical,laboratory and echocardiographic evaluation within 24 h of admission. Paediatric intensive care unit(PICU) admission was defined as severe disease. Results: We enrolled 50 cases of RSVB (median ageof 2 (1–6.5) months; 40% female) and 50 age-matched controls. We observed higher values of LVTX ininfants with RSVB than in controls (0.42 vs. 0.36; p = 0.008). Up to nine (18%) children presentedwith LVMD (LVTX > 0.5), with a higher incidence of PICU admission (89% vs. 5%; p < 0.001). Thediagnostic performance of NT-proBNP in predicting LVMD was high (area under the receiver operatorcharacteristic curve (AUC) 0.95, CI 95% 0.90–1). The diagnostic yield of the predictive model for PICUadmission that included NT-proBNP was excellent (AUC 0.945, CI 95% 0.880–1), and significantlyhigher than the model without NT-proBNP (p = 0.026). Conclusions: LVMD could be present inhealthy infants with RSVB who develop severe disease. NT-proBNP seems to improve traditionalclinical markers for outcomes.
PB MDPI
SN 2075-4418
YR 2019
FD 2019-09
LK http://hdl.handle.net/10498/21842
UL http://hdl.handle.net/10498/21842
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 11-nov-2026