RT journal article
T1 Conotoxin Diversity in the Venom Gland Transcriptome of the Magician’s Cone, Pionoconus magus
A1 Pardos-Blas, José R.
A1 Irisarri, Iker
A1 Abalde, Samuel
A1 Jiménez Tenorio, Manuel
A1 Zardoya, Rafael
A2 Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica
K1 RNA-seq
K1 D superfamily
K1 A alpha 4/3
K1 di erential expression
K1 O1 precursor phylogeny
AB The transcriptomes of the venom glands of two individuals of the magician’s cone,Pionoconus magus, from Okinawa (Japan) were sequenced, assembled, and annotated. In addition,RNA-seq raw reads available at the SRA database from one additional specimen of P. magus fromthe Philippines were also assembled and annotated. The total numbers of identified conotoxinprecursors and hormones per specimen were 118, 112, and 93. The three individuals shared onlyfive identical sequences whereas the two specimens from Okinawa had 30 sequences in common.The total number of distinct conotoxin precursors and hormones for P. magus was 275, and wereassigned to 53 conotoxin precursor and hormone superfamilies, two of which were new based on theirdivergent signal region. The superfamilies that had the highest number of precursors were M (42), O1(34), T (27), A (18), O2 (17), and F (13), accounting for 55% of the total diversity. The D superfamily,previously thought to be exclusive of vermivorous cones was found in P. magus and contained ahighly divergent mature region. Similarly, the A superfamily alpha 4/3 was found in P. magus despitethe fact that it was previously postulated to be almost exclusive of the genus Rhombiconus. Di erentialexpression analyses of P. magus compared to Chelyconus ermineus, the only fish-hunting cone from theAtlantic Ocean revealed that M and A2 superfamilies appeare
PB MDPI
SN 1660-3397
YR 2019
FD 2019-10
LK http://hdl.handle.net/10498/21982
UL http://hdl.handle.net/10498/21982
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 15-nov-2026