RT journal article
T1 Mapping the Biotransformation of Coumarins through Filamentous Fungi
A1 do Nascimento, Jainara Santos
A1 Rozo Núñez, Wilson Elias
A1 Pereira dos Santos, Valmore Henrique
A1 Aleu Casatejada, Josefina
A1 Cunha, Sílvio
A1 de Oliveira Silva, Eliane
A2 Química Orgánica
K1 coumarin
K1 biotransformation
K1 filamentous fungi
K1 selective hydroxylation
AB Natural coumarins are present in remarkable amounts as secondary metabolites in edible andmedicinal plants, where they display interesting bioactivities. Considering the wide enzymatic arsenalof filamentous fungi, studies on the biotransformation of coumarins using these microorganismshave great importance in green chemical derivatization. Several reports on the biotransformation ofcoumarins using fungi have highlighted the achievement of chemical analogs with high selectivityby using mild and ecofriendly conditions. Prompted by the enormous pharmacological, alimentary,and chemical interest in coumarin-like compounds, this study evaluated the biotransformationof nine coumarin sca olds using Cunninghamella elegans ATCC 10028b and Aspergillus brasiliensisATCC 16404. The chemical reactions which were catalyzed by the microorganisms were highlyselective. Among the nine studied coumarins, only two of them were biotransformed. One of thecoumarins, 7-hydroxy-2,3-dihydrocyclopenta[c]chromen-4(1H)-one, was biotransformed into thenew 7,9-dihydroxy-2,3-dihydrocyclopenta[c]chromen-4(1H)-one, which was generated by selectivehydroxylation in an unactivated carbon. Our results highlight some chemical features of coumarincores that are important to biotransformation using filamentous fungi.
PB MDPI
SN 1420-3049
YR 2019
FD 2019-10
LK http://hdl.handle.net/10498/21990
UL http://hdl.handle.net/10498/21990
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026