RT journal article
T1 Evolution of the Proto Sex-Chromosome in Solea senegalensis
A1 Rodríguez Jiménez, María Esther
A1 Molina, Belén
A1 Merlo Torres, Manuel Alejandro
A1 Arias Pérez, Alberto
A1 García Angulo, Aglaya María
A1 Cross Pacheco, Ismael
A1 Liehr, Thomas
A1 Rebordinos González, Laureana
A2 BiomedicinaBiotecnología y Salud Pública
K1 Solea senegalensis
K1 genomic synteny
K1 repetitive sequences
K1 chromosome evolution
K1 sex chromosomes
K1 karyotype
AB Solea senegalensis is a flatfish belonging to the Soleidae family within the Pleuronectiformesorder. It has a karyotype of 2n = 42 (FN = 60; 6M + 4 SM + 8 St + 24 T) and a XX/XY system. The firstpair of metacentric chromosomes has been proposed as a proto sex-chromosome originated by aRobertsonian fusion between acrocentric chromosomes. In order to elucidate a possible evolutionaryorigin of this chromosome 1, studies of genomic synteny were carried out with eight fish species.A total of 88 genes annotated within of 14 BACs located in the chromosome 1 of S. senegalensis wereused to elaborate syntenic maps. Six BACs (BAC5K5, BAC52C17, BAC53B20, BAC84K7, BAC56H24,and BAC48P7) were distributed in, at least, 5 chromosomes in the species studied, and a group of fourgenes from BAC53B20 (grsf1, rufy3, slc4a4 and np r2) and genes from BAC48K7 (dmrt2, dmrt3, dmrt1,c9orf117, kank1 and fbp1) formed a conserved cluster in all species. The analysis of repetitive sequencesshowed that the number of retroelements and simple repeat per BAC showed its highest value in thesubcentromeric region where 53B20, 16E16 and 48K7 BACs were localized. This region contains all thedmrt genes, which are associated with sex determination in some species. In addition, the presence ofa satellite “chromosome Y” (motif length: 860 bp) was detected in this region. These findings allowedto trace an evolutionary trend for the large metacentric chromosome of S. senegalensis, throughoutdi erent rearrangements, which could be at an initial phase of di erentiation as sex chromosome.
PB MDPI
SN 1422-0067
YR 2019
FD 2019-10
LK http://hdl.handle.net/10498/22001
UL http://hdl.handle.net/10498/22001
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 11-nov-2026