RT journal article
T1 Continuous Positive Airway Pressure Treatment in Patients with Alzheimer's Disease: A Systematic Review
A1 Pérez Cabezas, Verónica
A1 Ruiz Molinero, María del Carmen
A1 Jiménez-Rejano, José-Jesús
A1 González Medina, Gloria
A1 Galán Mercant, Alejandro
A1 Martín Valero, Rocío
A2 Enfermería y Fisioterapia
K1 continuous positive airway pressure
K1 Alzheimer disease
K1 neurocognitive function
AB Background: Epidemiological studies have suggested a pathophysiological relationship between obstructive sleep apnea syndrome (OSAS) and Alzheimer's disease (AD). The aim of this study is to evaluate the treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in AD and its relationship with neurocognitive function improvement. Methods: Systematic review conducted following PRISMA's statements. Relevant studies were searched in MEDLINE, PEDro, SCOPUS, PsycINFO, Web of Science, CINAHL and SportDicus. Original studies in which CPAP treatment was developel in AD patients have been included. Results: 5 studies, 3 RCTs (Randomized controlled trials) and 2 pilot studies. In all RCTs the CPAP intervention was six weeks; 3 weeks of therapeutic CPAP vs. 3 weeks placebo CPAP (pCPAP) followed by 3 weeks tCPAP in patients with AD and OSA. The two pilot studies conducted a follow-up in which the impact on cognitive impairment was measured. Conclusions: CPAP treatment in AD patients decreases excessive daytime sleepiness and improves sleep quality. There are indications that cognitive deterioration function measured with the Mini Mental Scale decreases or evolves to a lesser extent in Alzheimer's patients treated with CPAP. Caregivers observe stabilization in disease progression with integration of CPAP. More research is needed on the topic presented.
PB MDPI
SN 2077-0383
YR 2020
FD 2020-01
LK http://hdl.handle.net/10498/22612
UL http://hdl.handle.net/10498/22612
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026