RT journal article
T1 Deposition of CAP/Antioxidants Systems on Silica Particles Using the Supercritical Antisolvent Process
A1 García Casas, Ignacio
A1 Montes Herrera, Antonio
A1 Valor Bravo, Diego
A1 Pereyra López, Clara María
A1 Martínez de la Ossa Fernández, Enrique José
A2 Ingeniería Química y Tecnología de Alimentos
K1 supercritical deposition
K1 quercetin
K1 mangiferin
K1 cellulose acetate phthalate
K1 supercritical antisolvent process
AB Supercritical carbon dioxide has been used to deposit co-precipitates of natural antioxidantswith a polymer onto silica microparticles. The supercritical antisolvent process (SAS) was carried outwith the antioxidants by introducing the silica microparticles into the precipitator vessel. Two di erentconfigurations were employed to pump the solution. In one configuration, the antioxidant and thepolymer were dissolved and injected together through a nozzle. In the second configuration, theantioxidant and the polymer were dissolved in di erent solutions and sprayed through di erentnozzles. The use of operating conditions significantly above the critical point (180 bar and 323 K)led to the formation of composites made up of co-precipitates and silica. Delivery profiles showedthat the presence of the polymer and the silica delayed release of the antioxidant into gastric media,thus protecting it and allowing its full delivery to the intestinal fluids to improve the e ectiveness ofthe antioxidant.
PB MDPI
SN 2076-3417
YR 2020
FD 2020-07
LK http://hdl.handle.net/10498/23512
UL http://hdl.handle.net/10498/23512
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026