RT journal article
T1 Circulating miR-330-3p in Late Pregnancy is Associated with Pregnancy Outcomes Among Lean Women with GDM
A1 Pfeiffer, Shona
A1 Sánchez-Lechuga, Begoña
A1 Donovan, Paul
A1 Halang, Luise
A1 Prehn, Jochen H. M.
A1 Campos Caro, Antonio
A1 Byrne, Maria M.
A1 López Tinoco, Cristina
A2 BiomedicinaBiotecnología y Salud Pública
A2 Medicina
AB Gestational Diabetes Mellitus (GDM) is characterised by insulin resistance accompanied by reduced beta-cell compensation to increased insulin demand, typically observed in the second and third trimester and associated with adverse pregnancy outcomes. There is a need for a biomarker that can accurately monitor status and predict outcome in GDM, reducing foetal-maternal morbidity and mortality risks. To this end, circulating microRNAs (miRNAs) present themselves as promising candidates, stably expressed in serum and known to play crucial roles in regulation of glucose metabolism. We analysed circulating miRNA profiles in a cohort of GDM patients (n=31) and nondiabetic controls (n=29) during the third trimester for miRNA associated with insulin-secretory defects and glucose homeostasis. We identified miR-330-3p as being significantly upregulated in lean women with GDM compared to nondiabetic controls. Furthermore, increased levels of miR-330-3p were associated with better response to treatment (diet vs. insulin), with lower levels associated with exogenous insulin requirement. We observed miR-330-3p to be significantly related to the percentage of caesarean deliveries, with miR-330-3p expression significantly higher in spontaneously delivered GDM patients. We report this strong novel association of circulating miR-330-3p with risk of primary caesarean delivery as a pregnancy outcome linked with poor maternal glycaemic control, strengthening the growing body of evidence for roles of diabetes-associated miRNAs in glucose homeostasis and adaptation to the complex changes related to pregnancy.
PB NATURE PUBLISHING GROUP
SN 2045-2322
YR 2020
FD 2020-01
LK http://hdl.handle.net/10498/23665
UL http://hdl.handle.net/10498/23665
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 13-nov-2026