RT info:eu-repo/semantics/article
T1 El justo medio: los trastornos del lenguaje ligados al desarrollo desde la óptica de la biología de sistemas
T2 The golden mean: A systems biology approach to developmental language disorders
A1 Benítez Burraco, Antonio
K1 developmental language disorders
K1 symptomatology
K1 aetiology
K1 clinical linguistics
K1 systems biology
K1 brain oscillations
K1 endophenotypes
K1 evo-devo
K1 trastornos del lenguaje ligados al desarrollo
K1 sintomatología
K1 etiología
K1 lingüística clínica
K1 biología de sistemas
K1 oscilaciones cerebrales
K1 endofenotipos
K1 troubles du développement du langage
K1 symptomatologie
K1 étiologie
K1 linguistique clinique
K1 biologie des systèmes
K1 oscillations cérébrales
K1 les endophénotypes
AB Current typologies ofdevelopmental language disorders aremostly based on symptomatic criteria.Nonetheless, they often fail tocategorize and characterize patientsunambiguously, essentially because ofthe widespread problems ofcomorbidity and heterogeneity.Likewise, they usually fail toincorporate etiological factors in aprecise way. These shortcomings areexpected to impact negatively ontherapies and the recovery of patient’sabilities. This paper advocates asystems biology approach todevelopmental language disorders,aimed to disentangle how the myriad ofbiological factors involved (at thebottom) interact complexly to regulatelanguage development and processing(at the surface). In particular, itadvocates a classification of disordersbased on intermediate-levelcomponents, like brain oscillations.This fresh approach to theetiopathogenesis of developmentallanguage disorders, which is morebiologically motivated and moretheoretically grounded, should allowidentify robust endophenotypes ofthese conditions, that can be used asreliable hallmarks for an earlier andmore accurate diagnosis.
PB Universidad de Cádiz
SN 1133-682X
YR 2020
FD 2020-09
LK http://hdl.handle.net/10498/23726
UL http://hdl.handle.net/10498/23726
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-abr-2021