RT journal article
T1 Synthesis of Degraded Limonoid Analogs as New Antibacterial Scaffolds against Staphylococcus aureus
A1 Ferrera Suanzes, Marta
A1 Prieto, Victoria
A1 Medina Olivera, Antonio Jesús
A1 Botubol Ares, José Manuel
A1 Galán Sánchez, Fátima
A1 Rodríguez Iglesias, Manuel Antonio
A1 Hernández Galán, Rosario
A1 Durán Peña, María Jesús
A2 BiomedicinaBiotecnología y Salud Pública
A2 Química Orgánica
K1 degraded limonoids
K1 drug design
K1 aureus
K1 MRSA
K1 drug-like properties
AB Staphylococcus aureusand methicillin-resistantStaphylococcus aureus(MRSA) have become serious infections in humans and ruminants.S. aureusstrains are showing rapid changes to develop resistance in traditional antibiotic-containing systems. In the continuous fierce fight against the emergent multi-drug resistant bacterial strains, straightforward and scalable synthetic procedures to produce new active molecules are in demand. Analysis of molecular properties points to degraded limonoids as promising candidates. In this article, we report a simple synthetic approach to obtain degraded limonoid analogs as scaffolds for new antibacterial molecules. The minimum inhibitory concentrations againstS. aureuswere evaluated for the stereoisomer mixtures by the broth microdilution method. Analysis of results showed that the acetylated derivatives were the most active of them all.
PB MDPI
SN 2079-6382
YR 2020
FD 2020-08
LK http://hdl.handle.net/10498/23832
UL http://hdl.handle.net/10498/23832
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026