RT journal article T1 Low dietary inclusion of nutraceuticals from microalgae improves feed efficiency and modifies intermediary metabolisms in gilthead sea bream (Sparus aurata) A1 Perera Bravet, Erick A1 Sánchez Ruiz, David A1 Sáez, María Isabel A1 Galafat, Alba A1 Barany Ruiz, Andre A1 Fernández Castro, Miriam A1 Vizcaíno, Antonio Jesús A1 Fuentes, Juan A1 Martínez, Tomás Francisco A1 Mancera Romero, Juan Miguel A1 Alarcón, Francisco Javier A1 Martos Sitcha, Juan Antonio A2 Biología AB The aim of this work was to evaluate two functional feeds for the gilthead seabream, Sparus aurata, containing low inclusion of two microalgae-based products (LB-GREENboost, LBGb; and LB-GUThealth, LBGh). Fish (12-13 g) were fed for 13 weeks a control diet or one of the four diets supplemented with both products at 0.5% or 1%. LBGb and LBGh did not affect specific growth rate or survival, but increased feed efficiency by decreasing feed intake and enlarging the intestines. LBGb increased hepatosomatic index and reduced cortisol levels in plasma, while both products lowered plasma lactate. Extensive metabolite and metabolic enzyme profiling revealed that microalgae supplementations, especially 1% LBGh: (i) decrease plasma lactate and increase hepatic glycogen, (ii) reduce hepatic gluconeogenesis, (iii) enhance hepatic lipogenic activity and lipid secretion, (iv) led fish to double triglyceride content in muscle and to stimulate its lipid oxidative capacity, and (v) increase the content of monounsaturated fatty acids and the omega-3 alpha-linolenic acid in muscle. This study demonstrates that both microalgae-based products are suited to improve feed efficiency and orchestrate significant changes in the intermediary metabolism in gilthead seabream juveniles. PB NATURE RESEARCH SN 2045-2322 YR 2020 FD 2020-10 LK http://hdl.handle.net/10498/24079 UL http://hdl.handle.net/10498/24079 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 21-sep-2026